Mitochondria reside at the crossroads of catabolic and anabolic metabolism—the essence of
life. How their structure and function are dynamically tuned in response to tissue-specific …

Recent developments in wearable and implanted devices have resulted in numerous,
unprecedented capabilities that generate increasingly detailed information about a user's …

The ever-increasing demands for clean and sustainable energy sources combined with
rapid advances in biointegrated portable or implantable electronic devices have stimulated …

Metabolites once considered solely in catabolism or anabolism turn out to have key
regulatory functions. Among these, the citric acid cycle intermediate succinate stands out …

Mitochondrial complex I is central to the pathological reactive oxygen species (ROS)
production that underlies cardiac ischemia–reperfusion (IR) injury. ND6-P25L mice are …

Cadmium (Cd) is a well-known heavy metal and environmental toxicant and pollutant
worldwide, being largely present in every kind of item such as plastic (toys), battery, paints …

Regulation of the turnover of complex I (CI), the largest mitochondrial respiratory chain
complex, remains enigmatic despite huge advancement in understanding its structure and …

Respiratory complex I is a redox-driven proton pump, accounting for a large part of the
electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis …

Highlights•Respiratory complex I (NADH: ubiquinone oxidoreductase) is a redox-driven
proton pump.•Bacterial MBH and plastid NDH are members of the complex I superfamily.• …

Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative
phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous …