Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Often associated with obesity, male infertility represents a widespread condition that
challenges the wellbeing of the couple. In this article, we provide a comprehensive and …

A ketogenic diet (KD) has been promoted as an obesity management diet, yet its underlying
mechanism remains elusive. Here we show that KD reduces energy intake and body weight …

Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins, follicle …

Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1)
or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism. Within …

Puberty onset is initiated by activation of neurons that secrete gonadotropin-releasing
hormone (GnRH). The timing and progression of puberty may depend upon temporal …

Background: Adequate dietary intake and nutritional status have important effects on brain
functions and on brain health. Energy intake and specific nutrients excess or deficiency from …

This article is part of a Special Issue “Puberty and Adolescence”. Reproduction is an energy-
demanding function. Accordingly, puberty is metabolically gated, as a means to prevent …

Albeit essential for perpetuation of species, reproduction is an energy-demanding function
that can be adjusted to body metabolic status. Reproductive maturation and function can be …

The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of
this peptide is currently under investigation. Here, we identified SPX along with a second …