The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …

Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

The mRNA cap structure is a major site of dynamic mRNA methylation. mRNA caps exist in
either the Cap1 or Cap2 form, depending on the presence of 2′-O-methylation on the first …

The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

DRB is a classic inhibitor of transcription elongation by RNA polymerase II (pol II). Since
DRB generally affects class II genes, factors involved in this process must play fundamental …

Terminal structure analysis of an insect cytoplasmic polyhedrosis virus (CPV) genome RNA
in the early 1970s at the National Institute of Genetics in Japan yielded a 2′-O-methylated …