[PDF][PDF] edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets
Abstract edgeR is an R/Bioconductor software package for differential analyses of
sequencing data in the form of read counts for genes or genomic features. Over the past 15 …
sequencing data in the form of read counts for genes or genomic features. Over the past 15 …
Opportunities and challenges in long-read sequencing data analysis
Long-read technologies are overcoming early limitations in accuracy and throughput,
broadening their application domains in genomics. Dedicated analysis tools that take into …
broadening their application domains in genomics. Dedicated analysis tools that take into …
Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology
Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …
molecular and cellular mechanisms underlying cognitive impairment remain poorly …
Multi-omic machine learning predictor of breast cancer therapy response
Breast cancers are complex ecosystems of malignant cells and the tumour
microenvironment. The composition of these tumour ecosystems and interactions within …
microenvironment. The composition of these tumour ecosystems and interactions within …
Neurotoxic reactive astrocytes induce cell death via saturated lipids
Astrocytes regulate the response of the central nervous system to disease and injury and
have been hypothesized to actively kill neurons in neurodegenerative disease,,,,–. Here we …
have been hypothesized to actively kill neurons in neurodegenerative disease,,,,–. Here we …
Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Abstract Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …
Single-cell multi-omics analysis of the immune response in COVID-19
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
Live-seq enables temporal transcriptomic recording of single cells
Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize
cellular heterogeneity. However, scRNA-seq requires lysing cells, which impedes further …
cellular heterogeneity. However, scRNA-seq requires lysing cells, which impedes further …
Distinct contributions of partial and full EMT to breast cancer malignancy
F Lüönd, N Sugiyama, R Bill, L Bornes, C Hager… - Developmental cell, 2021 - cell.com
Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-
differentiation where cancer cells transit between various stages of an EMT continuum …
differentiation where cancer cells transit between various stages of an EMT continuum …
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
The induction of type I interferons through the transcription factor interferon regulatory factor
3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation …
3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation …