Dopamine is an essential neurotransmitter for daily cognitive functions controlling many
neurophysiological processes including memory, cognition, and physical control …

It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …

Early and progressive dysfunctions of the dopaminergic system from the Ventral Tegmental
Area (VTA) have been described in Alzheimer's Disease (AD). During the long pre …

Abstract N6-methyladenosine (m6A) plays a crucial role in ischemic stroke, whereas the role
of methyltransferase-like 14 (METTL14) in ischemic stroke remains unknown. A model of …

The aim of this study was to analyze signaling pathways associated with differentially
expressed messenger RNAs in people with restless legs syndrome (RLS). Seventeen RLS …

The activation of NLRP3 inflammasome in microglia is critical for neuroinflammation during
postoperative cognitive dysfunction (POCD) induced by sevoflurane. However, the …

Previous studies have demonstrated a bidirectional relationship between inflammation and
depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat …

The inflammasome is a multiprotein complex involved in innate immunity that mediates the
inflammatory response leading to pyroptosis, which is a lytic, inflammatory form of cell death …

Sepsis-associated encephalopathy (SAE) is a collection of clinical syndromes resulting from
sepsis and characterized by widespread brain dysfunction. The high prevalence of SAE has …

Historically, aging research has largely centered on disease pathology rather than
promoting healthy aging. The World Health Organization's (WHO) policy framework (2015 …