Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it
is inherited from the mother or the father. Several phenomena can cause parent-of-origin …

In this chapter we will review both the rationale and experimental design for using
Heterogeneous Stock (HS) populations for fine-map** of complex traits in mice and rats …

Epigenetic modifications are important in the normal functioning of the cell, from regulating
dynamic expression of essential genes and associated proteins to repressing those that are …

Allele-specific expression (ASE) is a phenomenon in which one allele is preferentially
expressed over the other. Genetic and epigenetic factors cause ASE by altering the final …

Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and
neurological traits. Parent-of-origin effects can be modified by the environment, but the …

Our previous data have linked obesity with immune dysfunction. It is known that physical
exercise with dietary control has beneficial effects on immune function and the comorbidities …

Context-dependent genetic effects, including genotype-by-environment and genotype-by-
sex interactions, are a potential mechanism by which genetic variation of complex traits is …

Background The laboratory mouse is the most commonly used model for studying variation
in complex traits relevant to human disease. Here we present the whole-genome sequences …

Quantitative genetic studies in model organisms, particularly in mice, have been extremely
successful in identifying chromosomal regions that are associated with a wide variety of …

Background The liver plays a major role in regulating metabolic homeostasis and is vital for
nutrient metabolism. Identifying the genetic factors regulating these processes could lead to …