▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix
developed by cells in culture. They provide a structural link between the actin cytoskeleton …

Adhesive interactions play critical roles in directing the migration, proliferation, and
differentiation of cells; aberrations in such interactions can lead to pathological disorders …

Src is the best understood member of a family of 9 tyrosine kinases that regulates cellular
responses to extracellular stimuli. Activated mutants of Src are oncogenic. Using Src as an …

To facilitate a rapid response to environmental change, cells use scaffolding—or adaptor—
proteins to recruit key components of their signal-transduction machinery to specific …

Cell adhesion is critical for the genesis and maintenance of both three-dimensional structure
and normal function in tissues. The biochemical entities mediating cell adhesion are …

Paxillin is a focal adhesion-associated, phosphotyrosine-containing protein that may play a
role in several signaling pathways. Paxillin contains a number of motifs that mediate protein …

Spermatogenesis is an intriguing but complicated biological process. However, many
studies since the 1960s have focused either on the hormonal events of the hypothalamus …

Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and
integration of multiple signaling pathways to effect the optimal cellular response to changes …