In the field of asymmetric synthesis, nonracemic sulfoxides are recognized as valuable and
efficient reagents. Their extensive use as chiral auxiliaries and intermediates is …

Flavin-containing monooxygenase (FMO) oxygenates drugs and xenobiotics containing a
“soft-nucleophile”, usually nitrogen or sulfur. FMO, like cytochrome P450 (CYP), is a …

Anthelmintic resistance in human and animal pathogenic helminths has been spreading in
prevalence and severity. Multidrug resistance is a widespread problem in livestock animals …

Parasitic helminths cause significant disease in animals and humans. In the absence of
alternative treatments, anthelmintics remain the principal agents for their control. Resistance …

Increasing anthelmintic resistance (AR) in livestock has stimulated growing efforts to monitor
anthelmintic effectiveness (AE) on livestock farms. On-farm assessment of AE relies on …

The drug-metabolizing enzymes that contribute to the metabolism or bioactivation of a drug
play a crucial role in defining the absorption, distribution, metabolism, and excretion …

Methylcarbamate benzimidazoles [albendazole (ABZ), fenbendazole (FBZ), and their
respective sulfoxide derivatives, albendazole sulfoxide (ABZSO) and oxfendazole (OXF)] are …

Arbidol is a broad-spectrum antiviral drug that is used clinically to treat influenza. In this
study, the pharmacokinetics, metabolism, and excretion of arbidol were investigated in …

Abstract Intranasal Microemulsions (MEs) for nose to brain delivery of a novel combination
of Albendazole sulfoxide (ABZ-SO) and Curcumin (CUR) for Neurocysticercosis (NCC), a …

Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)–
derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome …