B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Antibodies are versatile molecular binders with an established and growing role as
therapeutics. Computational approaches to develo** and designing these molecules are …

The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here,
we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput …

An individual's B cell receptor (BCR) repertoire encodes information about past immune
responses and potential for future disease protection. Deciphering the information stored in …

Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …

Therapeutic antibodies are the largest class of biotherapeutics and have been successful in
treating human diseases. However, the design and discovery of antibody drugs remains …

The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …

Antibodies are vital proteins of the immune system that recognize potentially harmful
molecules and initiate their removal. Mammals can efficiently create vast numbers of …

The adaptive immune system uses two main types of antigen receptors: T-cell receptors
(TCRs) and antibodies. While both proteins share a globally similar β-sandwich architecture …

Identifying the epitope of an antibody is a key step in understanding its function and its
potential as a therapeutic. Sequence-based clonal clustering can identify antibodies with …