New insights into the immunopathology and control of dengue virus infection
Dengue virus poses a major threat to global public health: two-thirds of the world's
population is now at risk from infection by this mosquito-borne virus. Dengue virus causes a …
population is now at risk from infection by this mosquito-borne virus. Dengue virus causes a …
Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms
AL Rothman - Nature Reviews Immunology, 2011 - nature.com
Dengue is a mosquito-borne viral disease of expanding geographical range and incidence.
The existence of four viral serotypes and the association of prior dengue virus infection with …
The existence of four viral serotypes and the association of prior dengue virus infection with …
Antibody-dependent enhancement of severe dengue disease in humans
For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to
enhance viral replication in vitro and severe disease in animal models. Although suspected …
enhance viral replication in vitro and severe disease in animal models. Although suspected …
Structural basis of Zika virus-specific antibody protection
H Zhao, E Fernandez, KA Dowd, SD Speer, DJ Platt… - Cell, 2016 - cell.com
Zika virus (ZIKV) infection during pregnancy has emerged as a global public health problem
because of its ability to cause severe congenital disease. Here, we developed six mouse …
because of its ability to cause severe congenital disease. Here, we developed six mouse …
Dengue viruses–an overview
A Tuiskunen Bäck, Å Lundkvist - Infection ecology & epidemiology, 2013 - Taylor & Francis
Dengue viruses (DENVs) cause the most common arthropod-borne viral disease in man
with 50–100 million infections per year. Because of the lack of a vaccine and antiviral drugs …
with 50–100 million infections per year. Because of the lack of a vaccine and antiviral drugs …
Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions
R De Alwis, SA Smith, NP Olivarez… - Proceedings of the …, 2012 - National Acad Sciences
Dengue is a mosquito-borne flavivirus that is spreading at an unprecedented rate and has
developed into a major health and economic burden in over 50 countries. Even though …
developed into a major health and economic burden in over 50 countries. Even though …
The human antibody response to dengue virus infection
WMPB Wahala, AM De Silva - Viruses, 2011 - mdpi.com
Dengue viruses (DENV) are the causative agents of dengue fever (DF) and dengue
hemorrhagic fever (DHF). Here we review the current state of knowledge about the human …
hemorrhagic fever (DHF). Here we review the current state of knowledge about the human …
Innate immunity to dengue virus infection and subversion of antiviral responses
Dengue is a major public health issue in tropical and subtropical regions worldwide. The
four serotypes of dengue virus (DENV1–DENV4) are spread primarily by Aedes aegypti and …
four serotypes of dengue virus (DENV1–DENV4) are spread primarily by Aedes aegypti and …
A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins
Abstract Dengue virus (DENV) infects~ 400 million people annually. There is no licensed
vaccine or therapeutic drug. Only a small fraction of the total DENV-specific antibodies in a …
vaccine or therapeutic drug. Only a small fraction of the total DENV-specific antibodies in a …
Dengue viruses cluster antigenically but not as discrete serotypes
The four genetically divergent dengue virus (DENV) types are traditionally classified as
serotypes. Antigenic and genetic differences among the DENV types influence disease …
serotypes. Antigenic and genetic differences among the DENV types influence disease …