For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekee** genes. Identification of Sp1's …

Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …

Curcumin, a yellow substance belonging to the polyphenols superfamily, is the active
component of turmeric, a common Indian spice, which is derived from the dried rhizome of …

Specificity protein 1 (Sp1) and other Sp and Krüppel-like factor (KLF) proteins are members
of a family of transcription factors which bind GC/GT-rich promoter elements through three …

There is evidence that specificity proteins (Sp), such as Sp1, Sp3, and Sp4, are
overexpressed in tumors and contribute to the proliferative and angiogenic phenotype …

17β-Estradiol (E2) binds to the estrogen receptor (ER) to activate gene expression or
repression and this involves both genomic (nuclear) and non-genomic (extranuclear …

Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-
anchored protein that binds with high-affinity and activates the serine protease uPA, thus …

Betulinic acid is a pentacyclic triterpene natural product initially identified as a melanoma-
specific cytotoxic agent that exhibits low toxicity in animal models. Subsequent studies show …

Pelvic lymph node metastases are regarded as the most important risk factor and a predictor
of poor prognosis for patients with cervical cancer. Exploration of metastasis-related …

Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-
inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease …