Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are
marked by their expression of CD301b. CD301b+ dermal DCs respond to allergens …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Background Although the cytokine IL-31 has been implicated in inflammatory and lymphoma-
associated itch, the cellular basis for its pruritic action is yet unclear. Objective We sought to …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This
information is processed by the spinal cord; however, the way in which this occurs is still …

Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also
contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and …

Introduction: Currently the treatment of chronic pain is inadequate and compromised by
debilitating central nervous system side effects. Here we discuss new therapeutic strategies …

Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation,
represents a cardinal feature of neuropathic pain. Blockade or ablation of high-threshold …