Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for
biomarker discovery and personalized medicine and has great potential to elucidate the …

Chronic kidney disease (CKD) has a high prevalence in the general population and is
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …

Aims Carnitine and choline are major nutrient precursors for gut microbiota-dependent
generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed …

Early detection and accurate monitoring of chronic kidney disease (CKD) could improve
care and retard progression to end-stage renal disease. Here, using untargeted …

From ontogenesis to homeostasis, the phenotypes of complex organisms are shaped by the
bidirectional interactions between the host organisms and their associated microbiota …

The prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality
rate continues to be unacceptably high. The biomarkers currently used in clinical practice …

Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease.
Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that …

In this review of the application of proteomics and metabolomics to kidney disease research,
we review key concepts, highlight illustrative examples, and outline future directions. The …

The high-throughput, high-resolution phenoty** enabled by metabolomics has been
applied increasingly to a variety of questions in nephrology research. This article provides …

Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …