Deciphering cell–cell interactions and communication from gene expression

E Armingol, A Officer, O Harismendy… - Nature Reviews …, 2021 - nature.com
Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …

Vascular endothelial cell development and diversity

E Trimm, K Red-Horse - Nature Reviews Cardiology, 2023 - nature.com
Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Robust map** of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues

D Pham, X Tan, B Balderson, J Xu, LF Grice… - Nature …, 2023 - nature.com
Spatial transcriptomics (ST) technologies generate multiple data types from biological
samples, namely gene expression, physical distance between data points, and/or tissue …

Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract

T Flerlage, DF Boyd, V Meliopoulos… - Nature Reviews …, 2021 - nature.com
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …

Capillary cell-type specialization in the alveolus

A Gillich, F Zhang, CG Farmer, KJ Travaglini, SY Tan… - Nature, 2020 - nature.com
In the mammalian lung, an apparently homogenous mesh of capillary vessels surrounds
each alveolus, forming the vast respiratory surface across which oxygen transfers to the …

Integrated single-cell atlas of endothelial cells of the human lung

JC Schupp, TS Adams, C Cosme Jr, MSB Raredon… - Circulation, 2021 - Am Heart Assoc
Background: Cellular diversity of the lung endothelium has not been systematically
characterized in humans. We provide a reference atlas of human lung endothelial cells …

The cellular and physiological basis for lung repair and regeneration: past, present, and future

MC Basil, J Katzen, AE Engler, M Guo, MJ Herriges… - Cell stem cell, 2020 - cell.com
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Vascular endothelial cells: heterogeneity and targeting approaches

JK Hennigs, C Matuszcak, M Trepel, J Körbelin - Cells, 2021 - mdpi.com
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

Endothelial AHR activity prevents lung barrier disruption in viral infection

J Major, S Crotta, K Finsterbusch, P Chakravarty… - Nature, 2023 - nature.com
Disruption of the lung endothelial–epithelial cell barrier following respiratory virus infection
causes cell and fluid accumulation in the air spaces and compromises vital gas exchange …

[HTML][HTML] Differential roles of regulatory T cells in acute respiratory infections

M Jovisic, N Mambetsariev, BD Singer… - The Journal of …, 2023 - Am Soc Clin Investig
JCI - Differential roles of regulatory T cells in acute respiratory infections Go to JCI Insight About
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