In this article, we provide a fresh perspective on the developmental origins of neuroticism—a
dimension of temperament marked by elevated stress reactivity resulting in the frequent …

Blunted stress reactivity resulting from early exposure to stress during childhood and
adolescence may increase vulnerability to addiction. Early life adversity (ELA) affects brain …

Neuroticism--the tendency to experience negative emotions, along with the perception that
the world is filled with stressful, unmanageable challenges--is strongly associated with …

Amygdala function is of high interest for cognitive, social and psychiatric neuroscience,
emphasizing the need for reliable assessments in humans. Previous work has indicated …

Depression is a common and disabling psychiatric disorder with a complex etiology, which
includes predisposing risk genes and environmental stressors. Variation in the Catechol-O …

Since its theoretical inception, psychopathy has been considered by philosophers,
clinicians, theorists, and empirical researchers to be substantially and critically explained by …

Women show increased predisposition for certain psychiatric disorders, such as depression,
that are associated with disturbances in the integration of emotion and cognition. While this …

The importance of amygdala, hippocampus, and medial prefrontal cortex (mPFC) for the
integration of neural, endocrine, and affective stress processing was shown in healthy …

Trait anxiety has been associated with altered activity within corticolimbic pathways
connecting the amygdala and rostral anterior cingulate cortex (rACC), which receive rich …

Social anxiety disorder (SAD) is a disabling psychiatric disorder with a complex
pathogenesis. Studies indicate a genetic component in the development of SAD, but the …