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Prions
SB Prusiner - Proceedings of the National Academy of Sciences, 1998 - pnas.org
Prions are unprecedented infectious pathogens that cause a group of invariably fatal
neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present …
neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present …
Amyloid cross-seeding: mechanism, implication, and inhibition
Most neurodegenerative diseases such as Alzheimer's disease, type 2 diabetes, Parkinson's
disease, etc. are caused by inclusions and plaques containing misfolded protein …
disease, etc. are caused by inclusions and plaques containing misfolded protein …
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
Prions are proteins that adopt alternative conformations that become self-propagating; the
PrPSc prion causes the rare human disorder Creutzfeldt–Jakob disease (CJD). We report …
PrPSc prion causes the rare human disorder Creutzfeldt–Jakob disease (CJD). We report …
Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept
Intrinsically disordered proteins (IDPs) lack stable tertiary and/or secondary structures under
physiological conditions in vitro. They are highly abundant in nature and their functional …
physiological conditions in vitro. They are highly abundant in nature and their functional …
Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
GP Saborio, B Permanne, C Soto - Nature, 2001 - nature.com
Prions are the infectious agents responsible for transmissible spongiform encephalopathies.
The principal component of prions is the glycoprotein PrPSc, which is a conformationally …
The principal component of prions is the glycoprotein PrPSc, which is a conformationally …
Prions
The discovery of infectious proteins, denoted prions, was unexpected. After much debate
over the chemical basis of heredity, resolution of this issue began with the discovery that …
over the chemical basis of heredity, resolution of this issue began with the discovery that …
Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase
Bacterial cells sense their population density through a sophisticated cell–cell
communication system and trigger expression of particular genes when the density reaches …
communication system and trigger expression of particular genes when the density reaches …
Mammalian prions and their wider relevance in neurodegenerative diseases
J Collinge - Nature, 2016 - nature.com
Prions are notorious protein-only infectious agents that cause invariably fatal brain diseases
following silent incubation periods that can span a lifetime. These diseases can arise …
following silent incubation periods that can span a lifetime. These diseases can arise …
Prion diseases of humans and animals: their causes and molecular basis
J Collinge - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Prion diseases are transmissible neurodegenerative conditions that include
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) …
Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) …
Molecular analysis of prion strain variation and the aetiology of'new variant'CJD
Strains of transmissible spongiform encephalopathies are distinguished by differing physico-
chemical properties of PrPSc, the disease-related isoform of prion protein, which can be …
chemical properties of PrPSc, the disease-related isoform of prion protein, which can be …