It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …

Using induced pluripotent stem cells (iPSCs) to understand the mechanisms of neurological
disease holds great promise; however, there is a lack of well-curated lines from a large array …

Morphogens choreograph the generation of remarkable cellular diversity in the develo**
nervous system. Differentiation of stem cells in vitro often relies upon the combinatorial …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results
in the loss of motor function in the central nervous system (CNS) and ultimately death. The …

Progress in dementia research has been limited, with substantial gaps in our knowledge of
targets for prevention, mechanisms for disease progression, and disease-modifying …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that leads to
progressive disability and motor impairment. Existing therapies provide modest …

Astrocytes respond to injury, infection, and inflammation in the central nervous system by
acquiring reactive states in which they may become dysfunctional and contribute to disease …

Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by
motor neuron degeneration with additional involvement of non-neuronal cells, in particular …

Background Transplantation of stem cells for treating neurodegenerative disorders is a
promising future therapeutic approach. However, the molecular mechanism underlying the …