Solid-state NMR: Methods for biological solids

S Ahlawat, KR Mote, NA Lakomek… - Chemical Reviews, 2022 - ACS Publications
In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

Solid-state NMR spectroscopy

B Reif, SE Ashbrook, L Emsley, M Hong - Nature Reviews Methods …, 2021 - nature.com
Solid-state nuclear magnetic resonance (NMR) spectroscopy is an atomic-level method to
determine the chemical structure, 3D structure and dynamics of solids and semi-solids. This …

Atomic structure of the open SARS-CoV-2 E viroporin

J Medeiros-Silva, AJ Dregni, NH Somberg, P Duan… - Science …, 2023 - science.org
The envelope (E) protein of the SARS-CoV-2 virus forms cation-conducting channels in the
endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The …

Precise Distance Control and Functionality Adjustment of Frustrated Lewis Pairs in Metal–Organic Frameworks

W Chen, S Li, L Yi, Z Chen, Z Li, Y Wu… - Journal of the …, 2024 - ACS Publications
We report the construction of frustrated Lewis pairs (FLPs) in a metal–organic framework
(MOF), where both Lewis acid (LA) and Lewis base (LB) are fixed to the backbone. The …

Microtubule-binding core of the tau protein

N El Mammeri, AJ Dregni, P Duan, HK Wang… - Science …, 2022 - science.org
The protein tau associates with microtubules to maintain neuronal health. Posttranslational
modifications of tau interfere with this binding, leading to tau aggregation in …

De novo design of a transmembrane Zn2+-transporting four-helix bundle

NH Joh, T Wang, MP Bhate, R Acharya, Y Wu, M Grabe… - Science, 2014 - science.org
The design of functional membrane proteins from first principles represents a grand
challenge in chemistry and structural biology. Here, we report the design of a membrane …

Golgi-localized putative S-adenosyl methionine transporters required for plant cell wall polysaccharide methylation

H Temple, P Phyo, W Yang, JJ Lyczakowski… - Nature Plants, 2022 - nature.com
Polysaccharide methylation, especially that of pectin, is a common and important feature of
land plant cell walls. Polysaccharide methylation takes place in the Golgi apparatus and …

Altering the substitution and cross‐linking of glucuronoarabinoxylans affects cell wall architecture in Brachypodium distachyon

T Tryfona, Y Pankratova, D Petrik… - New …, 2024 - Wiley Online Library
The Poaceae family of plants provides cereal crops that are critical for human and animal
nutrition, and also, they are an important source of biomass. Interacting plant cell wall …

Protonation, tautomerization, and rotameric structure of histidine: a comprehensive study by magic-angle-spinning solid-state NMR

S Li, M Hong - Journal of the American Chemical Society, 2011 - ACS Publications
Histidine structure and chemistry lie at the heart of many enzyme active sites, ion channels,
and metalloproteins. While solid-state NMR spectroscopy has been used to study histidine …

Mechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMR

F Hu, W Luo, M Hong - Science, 2010 - science.org
The M2 protein of influenza viruses forms an acid-activated tetrameric proton channel. We
used solid-state nuclear magnetic resonance spectroscopy to determine the structure and …