Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …
from embryonic development, organ maintenance, and aging to the coordination of immune …
Fundamental mechanisms of regulated cell death and implications for heart disease
Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …
Lipid composition of the cancer cell membrane
Cancer cell possesses numerous adaptations to resist the immune system response and
chemotherapy. One of the most significant properties of the neoplastic cells is the altered …
chemotherapy. One of the most significant properties of the neoplastic cells is the altered …
Sphingolipid metabolism in cancer signalling and therapy
B Ogretmen - Nature Reviews Cancer, 2018 - nature.com
Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …
Obesity and dyslipidemia
J Vekic, A Zeljkovic, A Stefanovic, Z Jelic-Ivanovic… - Metabolism, 2019 - Elsevier
Obesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which
is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines …
is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines …
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy
BACKGROUND Sphingosine 1-phosphate (S1P), a product of membrane sphingolipid
metabolism, is secreted and acts through G protein–coupled S1P receptors (S1PRs) in …
metabolism, is secreted and acts through G protein–coupled S1P receptors (S1PRs) in …
Ubiquitin ligases: structure, function, and regulation
N Zheng, N Shabek - Annual review of biochemistry, 2017 - annualreviews.org
Ubiquitin E3 ligases control every aspect of eukaryotic biology by promoting protein
ubiquitination and degradation. At the end of a three-enzyme cascade, ubiquitin ligases …
ubiquitination and degradation. At the end of a three-enzyme cascade, ubiquitin ligases …
Tumor necrosis factor receptor-associated factor regulation of nuclear factor κB and mitogen-activated protein kinase pathways
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …
related proteins that transduces signals from members of TNFR superfamily and various …
Sphingolipid metabolites in inflammatory disease
M Maceyka, S Spiegel - Nature, 2014 - nature.com
Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …
The role of ceramide and sphingosine-1-phosphate in Alzheimer's disease and other neurodegenerative disorders
K Czubowicz, H Jęśko, P Wencel, WJ Lukiw… - Molecular …, 2019 - Springer
Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …