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A close look at BACE1 inhibitors for Alzheimer's disease treatment
Abstract Alzheimer's disease (AD), the most common cause of age-dependent dementia, is
one of the most significant healthcare problems worldwide. Aggravating this situation, drugs …
one of the most significant healthcare problems worldwide. Aggravating this situation, drugs …
Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies
Abstract Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the
elderly population, is characterized by progressive cognitive decline and pathological …
elderly population, is characterized by progressive cognitive decline and pathological …
Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice
H Zheng, P Xu, Q Jiang, Q Xu, Y Zheng, J Yan, H Ji… - Microbiome, 2021 - Springer
Background Modification of the gut microbiota has been reported to reduce the incidence of
type 1 diabetes mellitus (T1D). We hypothesized that the gut microbiota shifts might also …
type 1 diabetes mellitus (T1D). We hypothesized that the gut microbiota shifts might also …
[HTML][HTML] Amyloid beta and tau cooperate to cause reversible behavioral and transcriptional deficits in a model of Alzheimer's disease
A key knowledge gap blocking development of effective therapeutics for Alzheimer's disease
(AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of …
(AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of …
The beta amyloid dysfunction (BAD) hypothesis for Alzheimer's disease
H Hillen - Frontiers in Neuroscience, 2019 - frontiersin.org
Beta amyloid, Aβ 1–42, originally named as Amyloid A4 protein, is one of the most
investigated peptides in neuroscience and has attracted substantial interest since its …
investigated peptides in neuroscience and has attracted substantial interest since its …
Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease
Unbiased data-driven omic approaches are revealing the molecular heterogeneity of
Alzheimer disease. Here, we used machine learning approaches to integrate high …
Alzheimer disease. Here, we used machine learning approaches to integrate high …
[HTML][HTML] Neuroprotective effects of chronic resveratrol treatment and exercise training in the 3xTg-AD mouse model of Alzheimer's disease
To date, there is no cure or effective treatment for Alzheimer's disease (AD), a chronic
neurodegenerative condition that affects memory, language, and behavior. AD is …
neurodegenerative condition that affects memory, language, and behavior. AD is …
[HTML][HTML] CYP46A1 activation by efavirenz leads to behavioral improvement without significant changes in amyloid plaque load in the brain of 5XFAD mice
Efavirenz, the FDA-approved anti-retroviral medication, is evaluated in the clinical trial in
patients with mild cognitive impairment or early dementia due to Alzheimer's disease …
patients with mild cognitive impairment or early dementia due to Alzheimer's disease …
[HTML][HTML] Aβ and tau interact with metal ions, lipid membranes and peptide-based amyloid inhibitors: are these common features relevant in Alzheimer's disease?
In the last two decades, the amyloid hypothesis, ie, the abnormal accumulation of toxic Aβ
assemblies in the brain, has been considered the mainstream concept sustaining research …
assemblies in the brain, has been considered the mainstream concept sustaining research …
microRNAs as early biomarkers of Alzheimer's disease: A synaptic perspective
Pathogenic processes underlying Alzheimer's disease (AD) affect synaptic function from
initial asymptomatic stages, long time before the onset of cognitive decline and …
initial asymptomatic stages, long time before the onset of cognitive decline and …