Evaluation of skin absorption of drugs from topical and transdermal formulations

ALM Ruela, AG Perissinato, MES Lino… - Brazilian journal of …, 2016 - SciELO Brasil
The skin barrier function has been attributed to the stratum corneum and represents a major
challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a …

[PDF][PDF] Simulated biological fluids with possible application in dissolution testing

MRC Marques, R Loebenberg, M Almukainzi - Dissolution Technol, 2011 - academia.edu
This literature review is a compilation of the composition and, in most cases, the preparation
instructions for simulated biological fluids that may be used as dissolution media in the …

Hot melt extrusion (HME) for amorphous solid dispersions: predictive tools for processing and impact of drug–polymer interactions on supersaturation

AL Sarode, H Sandhu, N Shah, W Malick… - European Journal of …, 2013 - Elsevier
The processing parameters for HME have been evaluated and the impact of solid state
intermolecular drug–polymer interactions on supersaturation has been investigated. Poorly …

Dissolution testing for generic drugs: an FDA perspective

OM Anand, LX Yu, DP Conner, BM Davit - The AAPS journal, 2011 - Springer
In vitro dissolution testing is an important tool used for development and approval of generic
dosage forms. The objective of this article is to summarize how dissolution testing is used for …

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

JM Custodio, CY Wu, LZ Benet - Advanced drug delivery reviews, 2008 - Elsevier
The ability to predict drug disposition involves concurrent consideration of many chemical
and physiological variables and the effect of food on the rate and extent of availability adds …

[HTML][HTML] Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles

PB Shekhawat, VB Pokharkar - Acta pharmaceutica sinica B, 2017 - Elsevier
Oral drug absorption is a process influenced by the physicochemical and biopharmaceutical
properties of the drug and its inter-relationship with the gastrointestinal tract. Drug solubility …

Pectins as a universal medicine

O Zaitseva, A Khudyakov, M Sergushkina, O Solomina… - Fitoterapia, 2020 - Elsevier
The review outlines the main aspects of the use of pectin polysaccharides in medicine, both
as independent medicinal substances and as a material for creating systems for targeted …

Investigation and correlation of drug polymer miscibility and molecular interactions by various approaches for the preparation of amorphous solid dispersions

F Meng, A Trivino, D Prasad, H Chauhan - European Journal of …, 2015 - Elsevier
Curcumin (CUR) was used as a poorly soluble drug whereas polyvinyl pyrrolidone K90
(PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene …

Evolution of choice of solubility and dissolution media after two decades of biopharmaceutical classification system

N Bou-Chacra, KJC Melo, IAC Morales, ES Stippler… - The AAPS journal, 2017 - Springer
The introduction of the biopharmaceutics drug classification system (Biopharmaceutics
Classification System (BCS)), in 1995, provided a simple way to describe the …

Paediatric oral biopharmaceutics: key considerations and current challenges

HK Batchelor, N Fotaki, S Klein - Advanced drug delivery reviews, 2014 - Elsevier
The complex process of oral drug absorption is influenced by a host of drug and formulation
properties as well as their interaction with the gastrointestinal environment in terms of drug …