Advances in antimicrobial microneedle patches for combating infections

R Jamaledin, CKY Yiu, EN Zare, LN Niu… - Advanced …, 2020 - Wiley Online Library
Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional
topical administration because of poor drug penetration across the stratum corneum. This …

Amphotericin B and other polyenes—discovery, clinical use, mode of action and drug resistance

H Carolus, S Pierson, K Lagrou, P Van Dijck - Journal of Fungi, 2020 - mdpi.com
Although polyenes were the first broad spectrum antifungal drugs on the market, after 70
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …

[HTML][HTML] Mycotic keratitis—a global threat from the filamentous fungi

JJ Hoffman, MJ Burton, A Leck - Journal of Fungi, 2021 - mdpi.com
Mycotic or fungal keratitis (FK) is a sight-threatening disease, caused by infection of the
cornea by filamentous fungi or yeasts. In tropical, low and middle-income countries, it …

Fungal keratitis: Pathogenesis, diagnosis and prevention

L Niu, X Liu, Z Ma, Y Yin, L Sun, L Yang, Y Zheng - Microbial pathogenesis, 2020 - Elsevier
As a kind of serious, potentially sight-threatening corneal infections with poor prognosis,
fungal keratitis can bring a heavy economic burden to patients and seriously affect the …

Recent advances in diagnosis and treatment approaches in fungal keratitis: A narrative review

LA Ghenciu, AC Faur, SL Bolintineanu, MC Salavat… - Microorganisms, 2024 - mdpi.com
Fungal keratitis represents a potentially sight-threatening infection associated with poor
prognosis, as well as financial burden. Novel diagnostic methods include polymerase-chain …

Mesoporous zinc oxide-based drug delivery system offers an antifungal and immunoregulatory strategy for treating keratitis

L Gu, J Lin, Q Wang, F Meng, G Niu, H Lin… - Journal of Controlled …, 2024 - Elsevier
Fungal keratitis is a refractory eye disease that is prone to causing blindness. Fungal
virulence and inflammatory responses are two major factors that accelerate the course of …

[HTML][HTML] Using slit-lamp images for deep learning-based identification of bacterial and fungal keratitis: model development and validation with different convolutional …

N Hung, AKY Shih, C Lin, MT Kuo, YS Hwang, WC Wu… - Diagnostics, 2021 - mdpi.com
In this study, we aimed to develop a deep learning model for identifying bacterial keratitis
(BK) and fungal keratitis (FK) by using slit-lamp images. We retrospectively collected slit …

Clinical characteristics and outcomes of fungal keratitis in the United Kingdom 2011–2020: a 10-year study

DSJ Ting, M Galal, B Kulkarni, MS Elalfy, D Lake… - Journal of Fungi, 2021 - mdpi.com
Fungal keratitis (FK) is a serious ocular infection that often poses significant diagnostic and
therapeutic dilemmas. This study aimed to examine the causes, clinical characteristics …

Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: Recent progress and contemporary research

M Pandey, H Choudhury, A binti Abd Aziz… - Polymers, 2021 - mdpi.com
Eyesight is one of the most well-deserved blessings, amid all the five senses in the human
body. It captures the raw signals from the outside world to create detailed visual images …

[HTML][HTML] The use of in vivo confocal microscopy in fungal keratitis–Progress and challenges

IM Bakken, CJ Jackson, TP Utheim, E Villani… - The ocular …, 2022 - Elsevier
Fungal keratitis (FK) is a serious and sight-threatening corneal infection with global reach.
The need for prompt diagnosis is paramount, as a delay in initiation of treatment could lead …