The review of current knowledge on neutrophil gelatinase-associated lipocalin (NGAL)

K Romejko, M Markowska, S Niemczyk - International journal of molecular …, 2023 - mdpi.com
Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein that is secreted
mostly by immune cells such as neutrophils, macrophages, and dendritic cells. Its production …

[HTML][HTML] Tumor-associated neutrophils and neutrophil-targeted cancer therapies

H Que, Q Fu, T Lan, X Tian, X Wei - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Neutrophils are the frontline cells in response to microbial infections and are involved in a
range of inflammatory disorders in the body. In recent years, neutrophils have gained …

[HTML][HTML] MMP9: a tough target for targeted therapy for cancer

K Augoff, A Hryniewicz-Jankowska, R Tabola, K Stach - Cancers, 2022 - mdpi.com
Simple Summary MMP9, due to its proteolytic activity, plays a key role in tumorigenesis by
regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells …

Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: recent advances

H Huang - Sensors, 2018 - mdpi.com
As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a
significant protease which plays vital roles in many biological processes. MMP-9 can cleave …

Adipokine dysregulation and adipose tissue inflammation in human obesity

X Unamuno, J Gómez‐Ambrosi… - European journal of …, 2018 - Wiley Online Library
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …

Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer

N Chaudhary, BS Choudhary, SG Shah… - … Journal of Cancer, 2021 - Wiley Online Library
Lipocalin 2 is a siderophore‐binding protein that regulates iron homeostasis. Lipocalin 2
expression is elevated in multiple tumor types; however, the mechanisms that drive tumor …

The evolution and heterogeneity of neutrophils in cancers: origins, subsets, functions, orchestrations and clinical applications

S Liu, W Wu, Y Du, H Yin, Q Chen, W Yu, W Wang… - Molecular Cancer, 2023 - Springer
Neutrophils, the most prevalent innate immune cells in humans, have garnered significant
attention in recent years due to their involvement in cancer progression. This comprehensive …

Metalloproteinases and wound healing

MP Caley, VLC Martins, EA O'Toole - Advances in wound care, 2015 - liebertpub.com
Significance: Matrix metalloproteinases (MMPs) are present in both acute and chronic
wounds. They play a pivotal role, with their inhibitors, in regulating extracellular matrix …

Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2

O Adler, Y Zait, N Cohen, R Blazquez, H Doron… - Nature cancer, 2023 - nature.com
Brain metastasis still encompass very grim prognosis and therefore understanding the
underlying mechanisms is an urgent need toward develo** better therapeutic strategies …

Matrix metalloproteinase-9: Many shades of function in cardiovascular disease

A Yabluchanskiy, Y Ma, RP Iyer, ME Hall… - …, 2013 - journals.physiology.org
Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates
pathological remodeling processes that involve inflammation and fibrosis in cardiovascular …