Tryptophan biochemistry: structural, nutritional, metabolic, and medical aspects in humans
L Palego, L Betti, A Rossi… - Journal of amino …, 2016 - Wiley Online Library
L‐Tryptophan is the unique protein amino acid (AA) bearing an indole ring: its
biotransformation in living organisms contributes either to kee** this chemical group in …
biotransformation in living organisms contributes either to kee** this chemical group in …
Rationally designed peptides and peptidomimetics as inhibitors of amyloid-β (Aβ) aggregation: Potential therapeutics of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …
Peptide‐based molecular strategies to interfere with protein misfolding, aggregation, and cell degeneration
V Armiento, A Spanopoulou… - Angewandte Chemie …, 2020 - Wiley Online Library
Protein misfolding into amyloid fibrils is linked to more than 40 as yet incurable cell‐and
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and type 2 …
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and type 2 …
Benzofuran and indole: promising scaffolds for drug development in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
[HTML][HTML] Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases
Bioactive peptides are actively involved in different biological functions and importantly
contribute to human health, and the use of peptides as therapeutics has a long successful …
contribute to human health, and the use of peptides as therapeutics has a long successful …
Design of LVFFARK and LVFFARK-functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity
Aggregation of amyloid β-protein (Aβ) into amyloid oligomers and fibrils is pathologically
linked to Alzheimer's disease (AD). Hence, the inhibition of Aβ aggregation is essential for …
linked to Alzheimer's disease (AD). Hence, the inhibition of Aβ aggregation is essential for …
Tau aggregation inhibiting peptides as potential therapeutics for Alzheimer disease
I Aillaud, SA Funke - Cellular and Molecular Neurobiology, 2023 - Springer
Alzheimer disease (AD) is the most common progressive neurodegenerative disorder. AD
causes enormous personal and economic burden to society as currently only limited …
causes enormous personal and economic burden to society as currently only limited …
Insights into the pathophysiology of Alzheimer's disease and potential therapeutic targets: A current perspective
K Rajah Kumaran, S Yunusa, E Perimal… - Journal of …, 2023 - content.iospress.com
The aging population increases steadily because of a healthy lifestyle and medical
advancements in healthcare. However, Alzheimer's disease (AD) is becoming more …
advancements in healthcare. However, Alzheimer's disease (AD) is becoming more …
Natural tripeptide-based inhibitor of multifaceted amyloid β toxicity
K Rajasekhar, C Madhu… - ACS chemical …, 2016 - ACS Publications
Accumulation of amyloid beta (Aβ) peptide and its aggregates in the human brain is
considered as one of the hallmarks of Alzheimer's disease (AD). The polymorphic oligomers …
considered as one of the hallmarks of Alzheimer's disease (AD). The polymorphic oligomers …
Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer's Disease?
In the last two decades, the amyloid hypothesis, ie, the abnormal accumulation of toxic Aβ
assemblies in the brain, has been considered the mainstream concept sustaining research …
assemblies in the brain, has been considered the mainstream concept sustaining research …