Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …

Epithelial ovarian cancer represents the most lethal gynecological malignancy in the
developed world, and can be divided into five main histological subtypes: high grade …

Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue
and not only perturb the tumour signal in molecular studies but also have an important role …

We have profiled, for the first time, an evolving human metastatic microenvironment by
measuring gene expression, matrisome proteomics, cytokine and chemokine levels …

Background Ovarian cancer (OV) is the most lethal gynecological cancer in women. We aim
to develop a generalized, individualized immune prognostic signature that can stratify and …

The inter-differentiation between cell states promotes cancer cell survival under stress and
fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience …

The emerging role of the cancer cell-immune cell interface in sha** tumorigenesis/
anticancer immunotherapy has increased the need to identify prognostic biomarkers …

Background Ovarian cancer causes more than 15000 deaths per year in the United States.
The survival of patients is quite heterogeneous, and accurate prognostic tools would help …

Two strategies are often adopted for enrichment analysis of pathways: the analysis of all
differentially expressed (DE) genes together or the analysis of up-and downregulated genes …