Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …

Physical exercise improves motor performance in individuals with Parkinson9s disease and
elevates mood in those with depression. Although underlying factors have not been …

Despite numerous studies on the neurobiology of depression, the etiological and
pathophysiological mechanisms of this disorder remain poorly understood. A large number …

Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Chronic stress is a major risk factor for depression onset. However, it remains unclear how
repeated stress sculpts neural circuits and finally elicits depression. Given the essential role …

Whether burnout is a form of depression or a distinct phenomenon is an object of
controversy. The aim of the present article was to provide an up-to-date review of the …

Background Depression is a heterogeneous disorder, with the exact neuronal mechanisms
causing the disease yet to be discovered. Recent work suggests it is accompanied by neuro …

Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

Depression has become one of the most severe psychiatric disorders and endangers the
health of living beings all over the world. In order to explore the molecular mechanism that …