The fibroblast growth factor signaling pathway
DM Ornitz, N Itoh - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
Advances and challenges in targeting FGFR signalling in cancer
IS Babina, NC Turner - Nature Reviews Cancer, 2017 - nature.com
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular
processes. Deregulation of FGFR signalling is observed in a subset of many cancers …
processes. Deregulation of FGFR signalling is observed in a subset of many cancers …
Negative feedback regulation of the ERK1/2 MAPK pathway
D Lake, SAL Corrêa, J Müller - Cellular and Molecular Life Sciences, 2016 - Springer
The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase
(MAPK) signalling pathway regulates many cellular functions, including proliferation …
(MAPK) signalling pathway regulates many cellular functions, including proliferation …
Targeting FGFR signaling in cancer
The fibroblast growth factor signaling pathway (FGFR signaling) is an evolutionary
conserved signaling cascade that regulates several basic biologic processes, including …
conserved signaling cascade that regulates several basic biologic processes, including …
Functional roles of JNK and p38 MAPK signaling in nasopharyngeal carcinoma
c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members integrate signals that affect proliferation, differentiation, survival, and migration in a …
members integrate signals that affect proliferation, differentiation, survival, and migration in a …
Fibroblast growth factor receptor inhibitors as a cancer treatment: from a biologic rationale to medical perspectives
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling pathway
plays a fundamental role in many physiologic processes, including embryogenesis, adult …
plays a fundamental role in many physiologic processes, including embryogenesis, adult …
Diverse mechanisms of BRAF inhibitor resistance in melanoma identified in clinical and preclinical studies
SA Luebker, SA Koepsell - Frontiers in oncology, 2019 - frontiersin.org
BRAF inhibitor therapy may provide profound initial tumor regression in metastatic
melanoma with BRAF V600 mutations, but treatment resistance often leads to disease …
melanoma with BRAF V600 mutations, but treatment resistance often leads to disease …
[HTML][HTML] Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors
The fibroblast growth factor receptor (FGFR) cascade plays crucial roles in tumor cell
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …
Mechanisms of acquired BRAF inhibitor resistance in melanoma: a systematic review
I Proietti, N Skroza, N Bernardini, E Tolino, V Balduzzi… - Cancers, 2020 - mdpi.com
Simple Summary Patients with advanced melanoma are often treated with v-raf murine
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …
Inhibition of RAF isoforms and active dimers by LY3009120 leads to anti-tumor activities in RAS or BRAF mutant cancers
SB Peng, JR Henry, MD Kaufman, WP Lu, BD Smith… - Cancer cell, 2015 - cell.com
LY3009120 is a pan-RAF and RAF dimer inhibitor that inhibits all RAF isoforms and
occupies both protomers in RAF dimers. Biochemical and cellular analyses revealed that …
occupies both protomers in RAF dimers. Biochemical and cellular analyses revealed that …