Same substrate, many reactions: oxygen activation in flavoenzymes
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Flavin dependent monooxygenases
MME Huijbers, S Montersino, AH Westphal… - Archives of biochemistry …, 2014 - Elsevier
Flavin-dependent monooxygenases catalyze a wide variety of chemo-, regio-and
enantioselective oxygenation reactions. As such, they are involved in key biological …
enantioselective oxygenation reactions. As such, they are involved in key biological …
An overview of microbial indigo-forming enzymes
AN Fabara, MW Fraaije - Applied Microbiology and Biotechnology, 2020 - Springer
Indigo is one of the oldest textile dyes and was originally prepared from plant material.
Nowadays, indigo is chemically synthesized at a large scale to satisfy the demand for dyeing …
Nowadays, indigo is chemically synthesized at a large scale to satisfy the demand for dyeing …
The enigmatic reaction of flavins with oxygen
The reaction of flavoenzymes with oxygen remains a fascinating area of research because
of its relevance for reactive oxygen species (ROS) generation. Several exciting recent …
of its relevance for reactive oxygen species (ROS) generation. Several exciting recent …
Unifying and versatile features of flavin-dependent monooxygenases: Diverse catalysis by a common C4a-(hydro) peroxyflavin
Flavin-dependent monooxygenases (FDMOs) are known for their remarkable versatility and
for their crucial roles in various biological processes and applications. Extensive research …
for their crucial roles in various biological processes and applications. Extensive research …
Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement
Flavoproteins catalyse a diversity of fundamental redox reactions and are one of the most
studied enzyme families,. As monooxygenases, they are universally thought to control …
studied enzyme families,. As monooxygenases, they are universally thought to control …
Two-component FAD-dependent monooxygenases: current knowledge and biotechnological opportunities
T Heine, WJH Van Berkel, G Gassner, KH Van Pée… - Biology, 2018 - mdpi.com
Flavoprotein monooxygenases create valuable compounds that are of high interest for the
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …
New frontiers in flavin-dependent monooxygenases
Flavin-dependent monooxygenases catalyze a wide variety of redox reactions in important
biological processes and are responsible for the synthesis of highly complex natural …
biological processes and are responsible for the synthesis of highly complex natural …
Monooxygenation of aromatic compounds by flavin‐dependent monooxygenases
Many flavoenzymes catalyze hydroxylation of aromatic compounds especially phenolic
compounds have been isolated and characterized. These enzymes can be classified as …
compounds have been isolated and characterized. These enzymes can be classified as …
Mechanism of oxygen activation in a flavin-dependent monooxygenase: a nearly barrierless formation of C4a-hydroperoxyflavin via proton-coupled electron transfer
Understanding how flavin-dependent enzymes activate oxygen for their oxidation and
oxygenation reactions is one of the most challenging issues in flavoenzymology. Density …
oxygenation reactions is one of the most challenging issues in flavoenzymology. Density …