The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains
the main characteristics of biological membranes, such as lipid bilayer, but differs from them …

The integrity of myelinated axons relies on homeostatic support from oligodendrocytes
(OLs). To determine how OLs detect axonal spiking and how rapid axon–OL metabolic …

Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …

Human hippocampal organoids (hHOs) derived from human induced pluripotent stem cells
(hiPSCs) have emerged as promising models for investigating neurodegenerative disorders …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …

Myelin, a lipid membrane that wraps axons, enabling fast neurotransmission and metabolic
support to axons, is conventionally thought of as a static structure that is set early in …

Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

Cognitive decline remains an unaddressed problem for the elderly. We show that
myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with …

Myelin, which is produced by oligodendrocytes, insulates axons to facilitate rapid and
efficient action potential propagation in the central nervous system. Traditionally viewed as a …