Control theory, a well-established discipline in engineering and mathematics, has found
novel applications in systems biology. This interdisciplinary approach leverages the …

Chemical and fuel production by photosynthetic cyanobacteria is a promising technology but
to date has not reached competitive rates and titers. Genome-scale metabolic modeling can …

Background Several methods have been developed to predict system-wide and condition-
specific intracellular metabolic fluxes by integrating transcriptomic data with genome-scale …

Background Although efficient l-tryptophan production using engineered Escherichia coli is
established from glucose, the use of alternative carbon sources is still very limited. Through …

Methylomicrobium buryatense 5GB1 is an obligate methylotroph which grows on methane
or methanol with similar growth rates. It has long been assumed that the core metabolic …

Understanding the symbiotic interaction between Coxiella‐like endosymbionts (CLE) and
their tick hosts is challenging due to lack of isolates and difficulties in tick functional assays …

Background Pichia pastoris shows physiological advantages in producing recombinant
proteins, compared to other commonly used cell factories. This yeast is mostly grown in …

Genome-scale metabolic models have proven highly valuable in investigating cell
physiology. Recent advances include the development of methods to extract context-specific …

The genome-scale models of metabolic networks have been broadly applied in phenotype
prediction, evolutionary reconstruction, community functional analysis, and metabolic …

Publishing repeatable and reproducible computational models is a crucial aspect of the
scientific method in computational biology and one that is often forgotten in the rush to …