Regulation of the inflammatory response in cardiac repair
NG Frangogiannis - Circulation research, 2012 - Am Heart Assoc
Myocardial necrosis triggers an inflammatory reaction that clears the wound from dead cells
and matrix debris, while activating reparative pathways necessary for scar formation. A …
and matrix debris, while activating reparative pathways necessary for scar formation. A …
Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix
in the heart, providing support to the contracting myocardium and contributing to a myriad of …
in the heart, providing support to the contracting myocardium and contributing to a myriad of …
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
LD Shultz, PA Schweitzer, SW Christianson… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
The scid mutation was backcrossed ten generations onto the NOD/Lt strain background,
resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive …
resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive …
Pathophysiology of myocardial infarction
NG Frangogiannis - Comprehensive Physiology, 2011 - Wiley Online Library
Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …
[PDF][PDF] Transforming growth factor-beta in disease: the dark side of tissue repair.
WA Border, E Ruoslahti - The Journal of clinical …, 1992 - Am Soc Clin Investig
Perspectives Page 1 Perspectives Transforming Growth Factor-,B in Disease: The Dark Side of
Tissue Repair Wayne A. Border* and Erkki Ruoslahtit *Division ofNephrology, University …
Tissue Repair Wayne A. Border* and Erkki Ruoslahtit *Division ofNephrology, University …
TGF-β1 and angiotensin networking in cardiac remodeling
S Rosenkranz - Cardiovascular research, 2004 - academic.oup.com
The renin–angiotensin system (RAS) and transforming growth factor-β1 (TGF-β1) play a
pivotal role in the development of cardiac hypertrophy and heart failure. Recent studies …
pivotal role in the development of cardiac hypertrophy and heart failure. Recent studies …
The immune system and cardiac repair
NG Frangogiannis - Pharmacological research, 2008 - Elsevier
Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …
a large number of myocardial cells. Because the heart has negligible regenerative capacity …
The Transforming Growth Factor-βs
AB Roberts, MB Sporn - Peptide growth factors and their receptors I, 1990 - Springer
Following the initial purification and characterization of transforming growth factor-p (TGF-p)
as a homodimeric, 25-kDa peptide (FROLIK et al. 1983; As-SOlAN et al. 1983; ROBERTS et …
as a homodimeric, 25-kDa peptide (FROLIK et al. 1983; As-SOlAN et al. 1983; ROBERTS et …
Physiological actions and clinical applications of transforming growth factor-β (TGF-β)
AB Roberts, MB Sporn - Growth factors, 1993 - Taylor & Francis
In the 10 years since its definition and characterization, TGF-β has come to be accepted as
the prototypical multifunctional peptide growth factor. Attempts to understand its mechanism …
the prototypical multifunctional peptide growth factor. Attempts to understand its mechanism …
Collagen remodeling after myocardial infarction in the rat heart.
JP Cleutjens, MJ Verluyten, JF Smiths… - The American journal …, 1995 - ncbi.nlm.nih.gov
In this study changes in the amount and distribution of types I and III collagen mRNA and
protein were investigated in the rat heart after induction of a left ventricular myocardial …
protein were investigated in the rat heart after induction of a left ventricular myocardial …