Nanodiscs in membrane biochemistry and biophysics

IG Denisov, SG Sligar - Chemical reviews, 2017 - ACS Publications
Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Mimicking the cell: bio-inspired functions of supramolecular assemblies

Y Tu, F Peng, A Adawy, Y Men… - Chemical …, 2016 - ACS Publications
The successful assembly of large supramolecular structures infers a delicate balance
between reversible noncovalent interactions which are capable of undergoing correction …

A saposin-lipoprotein nanoparticle system for membrane proteins

J Frauenfeld, R Löving, JP Armache, AFP Sonnen… - Nature …, 2016 - nature.com
A limiting factor in membrane protein research is the ability to solubilize and stabilize such
proteins. Detergents are used most often for solubilizing membrane proteins, but they are …

Covalently circularized nanodiscs for studying membrane proteins and viral entry

ML Nasr, D Baptista, M Strauss, ZYJ Sun, S Grigoriu… - Nature …, 2017 - nature.com
We engineered covalently circularized nanodiscs (cNDs) which, compared with standard
nanodiscs, exhibit enhanced stability, defined diameter sizes and tunable shapes …

Nanodiscs: A toolkit for membrane protein science

SG Sligar, IG Denisov - Protein Science, 2021 - Wiley Online Library
Membrane proteins are involved in numerous vital biological processes, including transport,
signal transduction and the enzymes in a variety of metabolic pathways. Integral membrane …

[HTML][HTML] Membrane protein assembly into Nanodiscs

TH Bayburt, SG Sligar - FEBS letters, 2010 - Elsevier
Nanodiscs are soluble nanoscale phospholipid bilayers which can self-assemble integral
membrane proteins for biophysical, enzymatic or structural investigations. This means for …

[HTML][HTML] Lipid membrane mimetics in functional and structural studies of integral membrane proteins

S Majeed, AB Ahmad, U Sehar, ER Georgieva - Membranes, 2021 - mdpi.com
Background: Open Access Editor's Choice Review Lipid Membrane Mimetics in Functional
and Structural Studies of Integral Membrane Proteins by Saman Majeed 1, Akram Bani …

Applications of phospholipid bilayer nanodiscs in the study of membranes and membrane proteins

A Nath, WM Atkins, SG Sligar - Biochemistry, 2007 - ACS Publications
Phospholipid bilayer Nanodiscs are novel model membranes derived from high-density
lipoprotein particles and have proven to be useful in studies of membrane proteins …

Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins

M Jamshad, V Grimard, I Idini, TJ Knowles, MR Dowle… - Nano Research, 2015 - Springer
In the past few years there has been a growth in the use of nanoparticles for stabilizing lipid
membranes that contain embedded proteins. These bionanoparticles provide a solution to …

Heat-shock proteins in neuroinflammation

B Dukay, B Csoboz, ME Tóth - Frontiers in pharmacology, 2019 - frontiersin.org
The heat-shock response, one of the main pro-survival mechanisms of a living organism,
has evolved as the biochemical response of cells to cope with heat stress. The most well …