Aggregation-induced emission (AIE), life and health

H Wang, Q Li, P Alam, H Bai, V Bhalla, MR Bryce… - ACS …, 2023‏ - ACS Publications
Light has profoundly impacted modern medicine and healthcare, with numerous
luminescent agents and imaging techniques currently being used to assess health and treat …

The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

HH Han, HM Wang, P Jangili, M Li, L Wu… - Chemical Society …, 2023‏ - pubs.rsc.org
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …

Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021‏ - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Apoptosis-amplified assembly of porphyrin nanofiber enhances photodynamic therapy of oral tumor

X Liu, W Zhan, G Gao, Q Jiang, X Zhang… - Journal of the …, 2023‏ - ACS Publications
Oral squamous cell carcinoma (OSCC) is the most common oral cancer, having high
recurrence and metastasis features. In addition to surgery, photodynamic therapy (PDT) is …

Nanoprobe-based molecular imaging for tumor stratification

X Ma, M Mao, J He, C Liang, HY **e - Chemical Society Reviews, 2023‏ - pubs.rsc.org
The responses of patients to tumor therapies vary due to tumor heterogeneity. Tumor
stratification has been attracting increasing attention for accurately distinguishing between …

Engineered metallacycle‐based supramolecular Photosensitizers for effective Photodynamic Therapy

L Tu, C Li, X **ong, J Hyeon Kim, Q Li, L Mei… - Angewandte …, 2023‏ - Wiley Online Library
Although metallacycle‐based supramolecular photosensitizers (PSs) have attracted
increasing attention in biomedicine, their clinical translation is still hindered by their inherent …

Near‐infrared photodynamic chemiluminescent probes for cancer therapy and metastasis detection

J Huang, C Zhang, X Wang, X Wei… - Angewandte Chemie, 2023‏ - Wiley Online Library
There is growing interest in the development of chemiluminescence (CL) probes for
phototheranostics because of their minimized tissue autofluorescence. However, due to a …

Activatable multimodal probes for in vivo imaging and theranostics

Y Wang, Y Hu, D Ye - Angewandte Chemie, 2022‏ - Wiley Online Library
Multimodal imaging, which harnesses two or more imaging modalities to produce
complementary anatomical and molecular information of a living subject, has become as a …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024‏ - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Self-assembled nano-PROTAC enables near-infrared photodynamic proteolysis for cancer therapy

W Wang, C Zhu, B Zhang, Y Feng… - Journal of the American …, 2023‏ - ACS Publications
Confining the protein degradation activity of proteolysis-targeting chimera (PROTAC) to
cancer lesions ensures precision treatment. However, it still remains challenging to precisely …