Targeting the NLRP3 inflammasome in severe COVID-19

TL Freeman, TH Swartz - Frontiers in immunology, 2020‏ - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Emergent biogeochemical risks from Arctic permafrost degradation

KR Miner, J D'Andrilli, R Mackelprang… - Nature Climate …, 2021‏ - nature.com
The Arctic cryosphere is collapsing, posing overlap** environmental risks. In particular,
thawing permafrost threatens to release biological, chemical and radioactive materials that …

Epidemics and trust: The case of the Spanish Flu

A Aassve, G Alfani, F Gandolfi… - Health economics, 2021‏ - Wiley Online Library
Recent studies argue that major crises can have long‐lasting effects on individual behavior.
While most studies focused on natural disasters, we explore the consequences of the global …

Back to the future: lessons learned from the 1918 influenza pandemic

KR Short, K Kedzierska… - Frontiers in cellular and …, 2018‏ - frontiersin.org
2018 marks the 100-year anniversary of the 1918 influenza pandemic, which killed~ 50
million people worldwide. The severity of this pandemic resulted from a complex interplay …

Ancient pathogen genomics as an emerging tool for infectious disease research

MA Spyrou, KI Bos, A Herbig, J Krause - Nature Reviews Genetics, 2019‏ - nature.com
Over the past decade, a genomics revolution, made possible through the development of
high-throughput sequencing, has triggered considerable progress in the study of ancient …

Large-scale de novo DNA synthesis: technologies and applications

S Kosuri, GM Church - Nature methods, 2014‏ - nature.com
For over 60 years, the synthetic production of new DNA sequences has helped researchers
understand and engineer biology. Here we summarize methods and caveats for the de novo …

Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments

RS Noyce, S Lederman, DH Evans - PloS one, 2018‏ - journals.plos.org
Edward Jenner and his contemporaries believed that his variolae vaccinae originated in
horses and molecular analyses show that modern vaccinia virus (VACV) strains share …

Contrasting characteristics, changes, and linkages of permafrost between the Arctic and the Third Pole

X Wang, Y Ran, G Pang, D Chen, B Su, R Chen… - Earth-Science …, 2022‏ - Elsevier
Permafrost degradation poses serious threats to both natural and human systems through its
influence on ecological–hydrological processes, infrastructure stability, and the climate …

[HTML][HTML] Smallpox in the post-eradication era

H Meyer, R Ehmann, GL Smith - Viruses, 2020‏ - mdpi.com
Widespread vaccination programmes led to the global eradication of smallpox, which was
certified by the World Health Organisation (WHO), and, since 1978, there has been no case …

The 1918 influenza pandemic: 100 years of questions answered and unanswered

JK Taubenberger, JC Kash, DM Morens - Science translational …, 2019‏ - science.org
The 2018–2019 period marks the centennial of the “Spanish” influenza pandemic, which
caused at least 50 million deaths worldwide. The unprecedented nature of the pandemic's …