The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …

Proteins tendency to bind to one another in a highly specific manner forming stable
complexes is fundamental to all biological processes. A better understanding of complex …

Protein–protein docking algorithms provide a means to elucidate structural details for
presently unknown complexes. Here, we present and evaluate a new method to predict …

Abstract The Fast Fourier Transform (FFT) correlation approach to protein–protein docking
can evaluate the energies of billions of docked conformations on a grid if the energy is …

Voltage-gated sodium, calcium, and potassium channels generate electrical signals
required for action potential generation and conduction and are the molecular targets for a …

The ability of proteins to establish highly selective interactions with a variety of (macro)
molecular partners is a crucial prerequisite to the realization of their biological functions. The …

Peptide-protein interactions are very prevalent, mediating key processes such as signal
transduction and protein trafficking. How can peptides overcome the entropic cost involved …

Mo lecular R ecognition F eatures (MoRFs) are short, interaction-prone segments of protein
disorder that undergo disorder-to-order transitions upon specific binding, representing a …

The recognition of protein interaction sites is an important intermediate step toward
identification of functionally relevant residues and understanding protein function, facilitating …

The recognition sites in 70 pairwise protein–protein complexes of known three‐dimensional
structure are dissected in a set of surface patches by clustering atoms at the interface. When …