Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …

Simple Summary Cancer represents unrestricted growth with the removal of conventional
brakes that control growth under normal conditions. This requires novel mechanisms to …

Overproduction of lactate (LA) can occur during exercise and in many diseases such as
cancers. Individuals with hyperlactatemia often display anemia, decreased serum iron, and …

M1 macrophages induce protective immunity against infection, but also contribute to
metabolic and inflammatory diseases. Here we show that the E3 ubiquitin ligase, MDM2 …

The accumulation of metabolites in the intervertebral disc is considered an important cause
of intervertebral disc degeneration (IVDD). Lactic acid, which is a metabolite that is produced …

Abstract Bcl-2-associated transcription factor-1 (BCLAF1), an apoptosis-regulating protein of
paramount significance, orchestrates the progression of various malignancies. This study …

Abstract Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of
the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which …

Lactylation, an emerging post-translational modification, plays a pivotal role in the initiation
and progression of digestive system tumors. This study presents a comprehensive review of …

Obesity occurs when overall energy intake surpasses energy expenditure. White adipose
tissue is an energy storage site, whereas brown and beige adipose tissues catabolize stored …

More than 619 million people in the world suffer from low back pain (LBP). As two potential
inducers of LBP, intervertebral disc degeneration (IVDD) and fat infiltration of paraspinal …