Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …

The COVID-19 pandemic placed the field of vaccinology squarely at the center of global
consciousness, emphasizing the vital role of vaccines as transformative public health tools …

Abstract Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection
against heterologous pathogens. However, the underlying mechanisms remain mysterious …

After a century of using the Bacillus Calmette–Guérin (BCG) vaccine, our understanding of
its ability to provide protection against homologous (Mycobacterium tuberculosis) or …

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of
death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille …

A subset of individuals exposed to Mycobacterium tuberculosis (Mtb) that we refer to as
'resisters'(RSTR) show evidence of IFN-γ− T cell responses to Mtb-specific antigens despite …

Mycobacterium tuberculosis (M. tb) is a bacterial pathogen that has evolved in humans, and
its interactions with the host are complex and best studied in humans. Myriad immune …

The absence of validated correlates of protection (CoPs) hampers the rational design and
clinical development of new tuberculosis vaccines. In this review, we provide an overview of …

B cells are important in tuberculosis (TB) immunity, but their role in the human lung is
understudied. Here, we characterize B cells from lung tissue and matched blood of patients …

A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of
adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis (M. tb) …