Fluid transport in the brain

MK Rasmussen, H Mestre… - Physiological …, 2022 - journals.physiology.org
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

The glymphatic system: Current understanding and modeling

T Bohr, PG Hjorth, SC Holst, S Hrabětová, V Kiviniemi… - IScience, 2022 - cell.com
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

[HTML][HTML] Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage

JH Yoon, H **, HJ Kim, SP Hong, MJ Yang, JH Ahn… - Nature, 2024 - nature.com
Cerebrospinal fluid (CSF) in the subarachnoid space around the brain has long been known
to drain through the lymphatics to cervical lymph nodes,,,,,,,,,,,,,,,–, but the connections and …

The glymphatic system: implications for drugs for central nervous system diseases

TJ Lohela, TO Lilius, M Nedergaard - Nature Reviews Drug Discovery, 2022 - nature.com
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

The glymphatic system: a novel component of fundamental neurobiology

LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - jneurosci.org
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

A mesothelium divides the subarachnoid space into functional compartments

K Møllgård, FRM Beinlich, P Kusk, LM Miyakoshi… - Science, 2023 - science.org
The central nervous system is lined by meninges, classically known as dura, arachnoid, and
pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the …

The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus

SM Robert, BC Reeves, E Kiziltug, PQ Duy, JK Karimy… - Cell, 2023 - cell.com
The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …

The glymphatic system (En) during inflammation

FLH Mogensen, C Delle, M Nedergaard - International journal of …, 2021 - mdpi.com
The glymphatic system is a fluid-transport system that accesses all regions of the brain. It
facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the …

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

RS Gomolka, LM Hablitz, H Mestre, M Giannetto, T Du… - Elife, 2023 - elifesciences.org
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …

Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage

T Du, A Raghunandan, H Mestre, V Plá, G Liu… - Nature Aging, 2024 - nature.com
Cervical lymphatic vessels (cLVs) have been shown to drain solutes and cerebrospinal fluid
(CSF) from the brain. However, their hydrodynamical properties have never been evaluated …