Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

In this review, we provide a brief synopsis of the connections between adipose tissue and
metabolic health and highlight some recent developments in understanding and exploiting …

Rationale: Long-term exercise provides reliable cardioprotection via mechanisms still
incompletely understood. Although traditionally considered a thermogenic tissue, brown …

In recent years, brown adipose tissue (BAT) has been recognized not only as a main site of
non-shivering thermogenesis in mammals, but also as an endocrine organ. BAT secretes a …

Decreased adipose tissue regulatory T cells contribute to insulin resistance in obese mice,
however, little is known about the mechanisms regulating adipose tissue regulatory T cells …

Exercise confers numerous salutary effects that extend beyond individual organ systems to
provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular …

Abstract Purpose of Review This review highlights aspects of brown adipose tissue (BAT)
communication with other organ systems and how BAT-to-tissue cross-talk could help …