A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in
diverse organisms. Here we review findings from budding and fission yeasts that reveal both …

Dynamic patterning of specific proteins is essential for the spatio-temporal regulation of
many important intracellular processes in prokaryotes, eukaryotes and multicellular …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Mathematical modeling has been instrumental in identifying common principles of cell
polarity across diverse systems. These principles include positive feedback loops that are …

How can a self-organized cellular function evolve, adapt to perturbations, and acquire new
sub-functions? To make progress in answering these basic questions of evolutionary cell …

Many eukaryotic cells grow by extending their cell periphery in pulses. The molecular
mechanisms underlying this process are not yet fully understood. Here we present a …

The development of organisms starting from their zygotic state involves a tight integration of
the myriad biochemical signaling interactions with the mechanical forces that eventually …

Rho-GTPases are master regulators of polarity establishment and cell morphology. Positive
feedback enables concentration of Rho-GTPases into clusters at the cell cortex, from where …

Background Many cells are remarkably proficient at tracking very shallow chemical
gradients, despite considerable noise from stochastic receptor-ligand interactions. Motile …

Many tip-growing cells are capable of responding to guidance cues, during which cells
precisely steer their growth toward the source of guidance signals. Though several players …