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The chemistry of heterocycles in the 21st century
VN Charushin, EV Verbitskiy, ON Chupakhin… - Uspekhi Khimii, 2024 - mathnet.ru
The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …
chemical science in Russia. This is due to the fact that many heterocycles find the widest …
Quinolines and structurally related heterocycles as antimalarials
The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …
natural compounds. The discovery of chloroquine, the most famous drug containing this …
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
Antimalarials from nature
Malaria is a major public health problem mainly due to the development of resistance by the
most lethal causative parasitic species, Plasmodium falciparum to the mainstay drugs like …
most lethal causative parasitic species, Plasmodium falciparum to the mainstay drugs like …
Quinoline-based antimalarial hybrid compounds
S Vandekerckhove, M D'hooghe - Bioorganic & medicinal chemistry, 2015 - Elsevier
Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …
Comprehensive review on various strategies for antimalarial drug discovery
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …
limiting our ability to manage this severe disease and finally lead to a massive global health …
Ferroquine and its derivatives: new generation of antimalarial agents
Malaria has been teasing human populations from a long time. Presently, several classes of
antimalarial drugs are available in market, but the issues of toxicity, lower efficacy and the …
antimalarial drugs are available in market, but the issues of toxicity, lower efficacy and the …
“Recycling” classical drugs for malaria
Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …
huge struggles made to date to fight this infection, in 2012 over half a million people were …
Amino acid based antimicrobial agents–synthesis and properties
Structures of several dozen of known antibacterial, antifungal or antiprotozoal agents are
based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial …
based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial …
Hybrid drugs for malaria
Malaria continues to devastate much of the tropics and sub-tropics in spite of the availability
of a number of antimalarial drugs. Part of this problem is due to the disadvantages of the …
of a number of antimalarial drugs. Part of this problem is due to the disadvantages of the …