Lipid droplets in the nervous system

I Ralhan, CL Chang, J Lippincott-Schwartz… - Journal of Cell …, 2021 - rupress.org
Lipid droplets are dynamic intracellular lipid storage organelles that respond to the
physiological state of cells. In addition to controlling cell metabolism, they play a protective …

Are reactive oxygen species always detrimental to pathogens?

CN Paiva, MT Bozza - Antioxidants & redox signaling, 2014 - liebertpub.com
Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …

Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells

JR Thomas, A Appios, X Zhao, R Dutkiewicz… - Journal of Experimental …, 2021 - rupress.org
Hofbauer cells (HBCs) are a population of macrophages found in high abundance within the
stroma of the first-trimester human placenta. HBCs are the only fetal immune cell population …

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

F Veglia, VA Tyurin, D Mohammadyani, M Blasi… - Nature …, 2017 - nature.com
Cross-presentation is a critical function of dendritic cells (DCs) required for induction of
antitumor immune responses and success of cancer immunotherapy. It is established that …

Lipid droplets and lipid mediators in viral infection and immunity

EA Monson, AM Trenerry, JL Laws… - FEMS microbiology …, 2021 - academic.oup.com
Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death

M Danielli, L Perne, E Jarc Jovičić… - Frontiers in Cell and …, 2023 - frontiersin.org
Lipid droplets are fat storage organelles ubiquitously distributed across the eukaryotic
kingdom. They have a central role in regulating lipid metabolism and undergo a dynamic …

Lipid droplets as immune modulators in myeloid cells

MH den Brok, TK Raaijmakers, E Collado-Camps… - Trends in …, 2018 - cell.com
Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are
increasingly recognized as dynamic players in lipid metabolism, with important roles not …

Foam cells: one size doesn't fit all

V Guerrini, ML Gennaro - Trends in immunology, 2019 - cell.com
Chronic inflammation in many infectious and metabolic diseases, and some cancers, is
accompanied by the presence of foam cells. These cells form when the intracellular lipid …

Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response

EA Monson, KM Crosse, M Duan, W Chen… - Nature …, 2021 - nature.com
Lipid droplets (LDs) are increasingly recognized as critical organelles in signalling events,
transient protein sequestration and inter-organelle interactions. However, the role LDs play …

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii

SJ Nolan, JD Romano, I Coppens - PLoS pathogens, 2017 - journals.plos.org
Toxoplasma is an obligate intracellular parasite that replicates in mammalian cells within a
parasitophorous vacuole (PV) that does not fuse with any host organelles. One mechanism …