Disease Trajectories from Healthcare Data: Methodologies, Key Results, and Future Perspectives

IF Jørgensen, AD Haue, D Placido… - Annual review of …, 2024 - annualreviews.org
Disease trajectories, defined as sequential, directional disease associations, have become
an intense research field driven by the availability of electronic population-wide healthcare …

Potential pitfalls in the use of real-world data for studying long COVID

HG Zhang, JP Honerlaw, M Maripuri… - Nature medicine, 2023 - nature.com
The value of large-scale, real-world data—from electronic health records (EHRs), for
example—has been used to establish vaccine efficacy, to elucidate the genetic etiologies of …

International electronic health record-derived post-acute sequelae profiles of COVID-19 patients

HG Zhang, A Dagliati, Z Shakeri Hossein Abad… - NPJ digital …, 2022 - nature.com
The risk profiles of post-acute sequelae of COVID-19 (PASC) have not been well
characterized in multi-national settings with appropriate controls. We leveraged electronic …

Informative missingness: What can we learn from patterns in missing laboratory data in the electronic health record?

ALM Tan, EJ Getzen, MR Hutch, ZH Strasser… - Journal of biomedical …, 2023 - Elsevier
Background In electronic health records, patterns of missing laboratory test results could
capture patients' course of disease as well as​​ reflect clinician's concerns or worries for …

A retrospective cohort analysis leveraging augmented intelligence to characterize long COVID in the electronic health record: a precision medicine framework

ZH Strasser, A Dagliati… - PLOS Digital …, 2023 - journals.plos.org
Physical and psychological symptoms lasting months following an acute COVID-19 infection
are now recognized as post-acute sequelae of COVID-19 (PASC). Accurate tools for …

[HTML][HTML] Seven Epidemic Waves of COVID-19 in a Hospital in Madrid: Analysis of Severity and Associated Factors

JV San Martín-López, N Mesa, D Bernal-Bello… - Viruses, 2023 - mdpi.com
(1) Background: COVID-19 has evolved during seven epidemic waves in Spain. Our
objective was to describe changes in mortality and severity in our hospitalized patients.(2) …

[HTML][HTML] Understanding Covid Vaccine Efficacy over Time—Bridging a Gap Between Public Health and Health Care

I Kohane, GS Omenn - New England Journal of Medicine, 2022 - Mass Medical Soc
Understanding Covid Vaccine Efficacy over Time — Bridging a Gap Between Public Health
and Health Care | New England Journal of Medicine Skip to main content The New England …

A Process Mining Pipeline to Characterize COVID-19 Patients' Trajectories and Identify Relevant Temporal Phenotypes From EHR Data

A Dagliati, R Gatta, A Malovini, V Tibollo… - Frontiers in Public …, 2022 - frontiersin.org
The impact of the COVID-19 pandemic involved the disruption of the processes of care and
the need for immediately effective re-organizational procedures. In the context of digital …

[HTML][HTML] Population risk factors for severe disease and mortality in COVID-19 in the United States during the pre-vaccine era: a retrospective cohort study of national …

K Raj, K Yeruva, K Jyotheeswara Pillai, P Kumar… - Medical …, 2022 - mdpi.com
Background-Previous studies on coronavirus disease 2019 (COVID-19) were limited to
specific geographical locations and small sample sizes. Therefore, we used the National …