Interstitial fluid pressure as an emerging biomarker in solid tumors
The physical microenvironment of cancer is characterized by elevated stiffness and tissue
pressure, the main component of which is the interstitial fluid pressure (IFP). Elevated IFP is …
pressure, the main component of which is the interstitial fluid pressure (IFP). Elevated IFP is …
Image-guided thermosensitive liposomes for focused ultrasound enhanced co-delivery of carboplatin and SN-38 against triple negative breast cancer in mice
Triggerable nanocarriers have the potential to significantly improve the therapeutic index of
existing anticancer agents. They allow for highly localised delivery and release of …
existing anticancer agents. They allow for highly localised delivery and release of …
[HTML][HTML] Challenges and opportunities of integrating imaging and mathematical modelling to interrogate biological processes
Advances in biological imaging have accelerated our understanding of human physiology in
both health and disease. As these advances have developed, the opportunities gained by …
both health and disease. As these advances have developed, the opportunities gained by …
Effect of vascular normalization on drug delivery to different stages of tumor progression: In-silico analysis
Vascular normalization (VN) by anti-angiogenic factors may be efficacious for improving
drug delivery in solid tumors. In the present study, a 3D computational model is employed to …
drug delivery in solid tumors. In the present study, a 3D computational model is employed to …
A mesoscale computational model for microvascular oxygen transfer
We address a mathematical model for oxygen transfer in the microcirculation. The model
includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen …
includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen …
Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media
The dynamics of blood flow in the smallest vessels and passages of the human body, where
the cellular character of blood becomes prominent, plays a dominant role in the transport …
the cellular character of blood becomes prominent, plays a dominant role in the transport …
[HTML][HTML] Optimal heat transport induced by magnetic nanoparticle delivery in vascularised tumours
We describe a novel mathematical model for blood flow, delivery of nanoparticles, and heat
transport in vascularised tumour tissue. The model, which is derived via the asymptotic …
transport in vascularised tumour tissue. The model, which is derived via the asymptotic …
Drug transport modeling in solid tumors: A computational exploration of spatial heterogeneity of biophysical properties
Inadequate uptake of therapeutic agents by tumor cells is still a major barrier in clinical
cancer therapy. Mathematical modeling is a powerful tool to describe and investigate the …
cancer therapy. Mathematical modeling is a powerful tool to describe and investigate the …
Modeling hypoxia-induced radiation resistance and the impact of radiation sources
Hypoxia contributes significantly to resistance in radiotherapy. Our research rigorously
examines the influence of microvascular morphology on radiotherapy outcome, specifically …
examines the influence of microvascular morphology on radiotherapy outcome, specifically …
Non-Invasive Assessment of the Spatial and Temporal Distributions of Interstitial Fluid Pressure, Fluid Velocity and Fluid Flow in Cancers In Vivo
Interstitial fluid pressure, interstitial fluid velocity and related parameters are of great clinical
significance for cancer diagnosis, prognosis and treatment. A limited number of non-invasive …
significance for cancer diagnosis, prognosis and treatment. A limited number of non-invasive …