Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release

N Kamaly, B Yameen, J Wu, OC Farokhzad - Chemical reviews, 2016‏ - ACS Publications
The development of biodegradable polymers represents a revolution in medicine spanning
over 50 years and leading to significant biotechnological advancements in drug delivery …

Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies

K Ulbrich, K Hola, V Subr, A Bakandritsos… - Chemical …, 2016‏ - ACS Publications
Targeted delivery combined with controlled drug release has a pivotal role in the future of
personalized medicine. This review covers the principles, advantages, and drawbacks of …

Evolution of drug delivery systems: From 1950 to 2020 and beyond

H Park, A Otte, K Park - Journal of Controlled Release, 2022‏ - Elsevier
Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-
release capsule technology, which can deliver a drug for 12 h after oral administration …

Self-assembling prodrugs

AG Cheetham, RW Chakroun, W Ma… - Chemical Society Reviews, 2017‏ - pubs.rsc.org
Covalent modification of therapeutic compounds is a clinically proven strategy to devise
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …

Particle toxicology and health-where are we?

M Riediker, D Zink, W Kreyling, G Oberdörster… - Particle and fibre …, 2019‏ - Springer
Background Particles and fibres affect human health as a function of their properties such as
chemical composition, size and shape but also depending on complex interactions in an …

Phase I Clinical and Pharmacokinetic Study of PK1 [N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin]: First Member of a New Class of Chemotherapeutic …

PA Vasey, SB Kaye, R Morrison, C Twelves… - Clinical cancer …, 1999‏ - aacrjournals.org
PK1 comprises doxorubicin covalently bound to N-(2-hydroxypropyl) methacrylamide
copolymer by a peptidyl linker. Following cellular uptake via pinocytosis, the linker is …

Stimuli-responsive polymers at the interface with biology

NRB Boase, ER Gillies, R Goh, RE Kieltyka… - …, 2024‏ - ACS Publications
There has been growing interest in polymeric systems that break down or undergo property
changes in response to stimuli. Such polymers can play important roles in biological …

Strategies for formulating and delivering poorly water-soluble drugs

M Rodriguez-Aller, D Guillarme, JL Veuthey… - Journal of Drug Delivery …, 2015‏ - Elsevier
Water solubility is a key parameter in drug formulation since it highly influences drug
pharmacokinetics and pharmacodynamics. In the past decades, the challenge with poorly …

Targeted drug delivery in cancer therapy

JK Vasir, V Labhasetwar - Technology in cancer research & …, 2005‏ - journals.sagepub.com
Chemotherapy has been the main modality of treatment for cancer patients; however, its
success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue …

HPMA copolymer–anticancer drug conjugates: design, activity, and mechanism of action

J Kopeček, P Kopečková, T Minko, ZR Lu - European journal of …, 2000‏ - Elsevier
The design, synthesis and properties of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics …