Despite the generally held view that alcohol is an unspecific pharmacological agent, recent
molecular pharmacology studies demonstrated that alcohol has only a few known primary …

The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …

N-arachidonoylethanolamine (anandamide) was the first endogenous cannabinoid receptor
ligand to be discovered. Dual synthetic pathways for anandamide have been proposed. One …

Alcoholism is a major public health problem and resembles, in many ways, other chronic
relapsing medical conditions. At least 2 separate dimensions of its symptomatology offer …

Background The “classic” endocannabinoid (eCB) system includes the cannabinoid
receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2 …

Marijuana is the world's most popular illicit drug, with hundreds of millions of regular users
worldwide. One in three Americans has smoked pot at least once. The Drug Enforcement …

The past decade has seen an expansion of research and knowledge on pharmacotherapy
for the treatment of alcohol dependence. The Food and Drug Administration (FDA)-approved …

The endocannabinoid anandamide (AEA) is shown to induce apoptotic bodies formation
and DNA fragmentation, hallmarks of programmed cell death, in human neuroblastoma …

The mechanisms underlying predisposition to alcohol abuse and alcoholism are poorly
understood. In this study, we evaluated the role of cannabinoid (CB1) receptors in (i) …

Nerve cells (ie, neurons) communicate via a combination of electrical and chemical signals.
Within the neuron, electrical signals driven by charged particles allow rapid conduction from …