Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 …
Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
Recent developments in biomarkers for diagnosis and screening of type 2 diabetes mellitus
Abstract Purpose of Review Diabetes mellitus is a complex, chronic illness characterized by
elevated blood glucose levels that occurs when there is cellular resistance to insulin action …
elevated blood glucose levels that occurs when there is cellular resistance to insulin action …
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity
Mitochondrial disorders represent a large collection of rare syndromes that are difficult to
manage both because we do not fully understand biochemical pathogenesis and because …
manage both because we do not fully understand biochemical pathogenesis and because …
Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients
We identified the main changes in serum metabolites associated with severe (n= 46) and
mild (n= 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The …
mild (n= 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The …
Recent progress on branched-chain amino acids in obesity, diabetes, and beyond
Branched-chain amino acids (BCAAs) are essential amino acids that are not synthesized in
our body; thus, they need to be obtained from food. They have shown to provide many …
our body; thus, they need to be obtained from food. They have shown to provide many …
Pathophysiology of type 2 diabetes in children and adolescents
Background: The prevalence of type 2 diabetes (DM) in children is disturbingly increasing in
parallel with the increasing childhood obesity. Better knowledge regarding the …
parallel with the increasing childhood obesity. Better knowledge regarding the …
Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial
Aims/hypothesis Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs)
are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and …
are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and …
Protein and amino acids in nonalcoholic fatty liver disease
Mechanistic studies in NAFLD have been mostly focused on carbohydrate and fat
metabolism, while little is known about the influence of protein and amino acids. Moreover …
metabolism, while little is known about the influence of protein and amino acids. Moreover …
A branched-chain amino acid-related metabolic signature characterizes obese adolescents with non-alcoholic fatty liver disease
Dysregulation of several metabolite pathways, including branched-chain amino acids
(BCAAs), are associated with Non-Alcoholic Fatty Liver Disease (NAFLD) and insulin …
(BCAAs), are associated with Non-Alcoholic Fatty Liver Disease (NAFLD) and insulin …
Which role plays 2-hydroxybutyric acid on insulin resistance?
AP Sousa, DM Cunha, C Franco, C Teixeira, F Gojon… - Metabolites, 2021 - mdpi.com
Type 2 Diabetes Mellitus (T2D) is defined as a chronic condition caused by beta cell loss
and/or dysfunction and insulin resistance (IR). The discovering of novel biomarkers capable …
and/or dysfunction and insulin resistance (IR). The discovering of novel biomarkers capable …