This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …

Abstract Purpose of Review Despite current rehabilitative strategies, stroke remains a
leading cause of disability in the USA. There is a window of enhanced neuroplasticity early …

Stroke is a leading cause of disability, but no pharmacological therapy is currently available
for promoting recovery. The brain region adjacent to stroke damage—the peri-infarct zone …

Stroke remains a leading cause of adult disability. Some degree of spontaneous behavioral
recovery is usually seen in the weeks after stroke onset. Variability in recovery is substantial …

Stroke instigates a dynamic process of repair and remodelling of remaining neural circuits,
and this process is shaped by behavioural experiences. The onset of motor disability …

In neurology, as in all branches of medicine, symptoms of disease and the resulting burden
of illness and disability are not simply the consequence of the injury, inflammation or …

After focal damage, cerebral networks reorganise their structural and functional anatomy to
compensate for both the lesion itself and remote effects. Novel developments in the analysis …

Animal models suggest that a month of heightened plasticity occurs in the brain after stroke,
accompanied by most of the recovery from impairment. This period of peri-infarct and remote …

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Matrix metalloproteinases (MMPs) are zinc-endopeptidases with multifactorial actions in
central nervous system (CNS) physiology and pathology. Accumulating data suggest that …