[HTML][HTML] Unlocking the mitochondria for nanomedicine-based treatments: overcoming biological barriers, improving designs, and selecting verification techniques

C Pegoraro, I Domingo-Ortí, I Conejos-Sánchez… - Advanced Drug Delivery …, 2024 - Elsevier
Enhanced targeting approaches will support the treatment of diseases associated with
dysfunctional mitochondria, which play critical roles in energy generation and cell survival …

[HTML][HTML] Red blood cell-derived materials for cancer therapy: construction, distribution, and applications

J Ding, X Ding, W Liao, Z Lu - Materials Today Bio, 2024 - Elsevier
Cancer has become an increasingly important public health issue owing to its high morbidity
and mortality rates. Although traditional treatment methods are relatively effective, they have …

Nebulized milk exosomes loaded with siTGF-β1 ameliorate pulmonary fibrosis by inhibiting EMT pathway and enhancing collagen permeability

C Qiu, Z Zhao, C Xu, R Yuan, Y Ha, Q Tu… - Journal of …, 2024 - Springer
Pulmonary Fibrosis (PF) is a fatal disease in the interstitial lung associated with high
mortality, morbidity, and poor prognosis. Transforming growth factor-β1 (TGF-β1) is a …

Red blood cell-derived extracellular vesicles display endogenous antiviral effects and enhance the efficacy of antiviral oligonucleotide therapy

MK Jayasinghe, C Gao, G Yap, BZJ Yeo, LT Vu… - ACS …, 2023 - ACS Publications
The COVID-19 pandemic has resulted in a large number of fatalities and, at present, lacks a
readily available curative treatment for patients. Here, we demonstrate that unmodified red …

[HTML][HTML] Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer

TTT Tran, C Dai Phung, BZJ Yeo, RC Prajogo… - …, 2024 - thelancet.com
Summary Background Tyrosine kinase inhibitors (TKIs) are currently the standard therapy
for patients with non-small cell lung cancer (NSCLC) bearing mutations in epidermal growth …

Biomimetic nanocarriers in cancer therapy: Based on intercellular and cell-tumor microenvironment communication

H Mengyuan, L Aixue, G Yongwei, C Qingqing… - Journal of …, 2024 - Springer
Inspired by the concept of “natural camouflage,” biomimetic drug delivery systems have
emerged to address the limitations of traditional synthetic nanocarriers, such as poor …

Therapeutic potential of miRNAs in placental extracellular vesicles in ovarian and endometrial cancer

Y Zhang, Y Tang, X Chen, X Sun, M Zhao, Q Chen - Human Cell, 2024 - Springer
There is a cross-link between the placenta and cancer development, as the placenta is
grown as a highly invasive tumour-like organ. However, placental development is strictly …

A pilot in vivo study: potential ovarian cancer therapeutic by placental extracellular vesicles

X Chen, S Tijono, B Tsai, LW Chamley… - Bioscience …, 2023 - portlandpress.com
The biological links between cancer and pregnancy are of interest due to parallel
proliferative, immunosuppressive, and invasive mechanisms between tumour and placental …

Extracellular vesicles efficiently deliver survival motor neuron protein to cells in culture

CA René, RJ Parks - Scientific Reports, 2025 - nature.com
Abstract Spinal Muscular Atrophy (SMA) is a genetic neuromuscular disorder caused by
homozygous mutation or deletion of the survival motor neuron 1 (SMN1) gene, leading to a …

Overcoming delivery barriers for RNA therapeutics in the treatment of rheumatoid arthritis

B Zhang, J Li, J Jiang, X Lin, X Sun, Q Wang - European Journal of …, 2023 - Elsevier
RNA therapeutics can manipulate gene expression or protein production, making them
suitable for treating a wide range of diseases. Theoretically, any disease that has a definite …