Radiographic axial spondyloarthritis (also known as ankylosing spondylitis [AS]) is a chronic
immune-mediated arthritis characterized by inflammation of the axial skeleton, peripheral …

Spondyloarthritis (SpA) represents a group of immune-mediated inflammatory diseases that
exhibit overlap** clinical features, genetic predisposition, and pathogenic mechanisms (1) …

Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily
the spine and pelvis. In addition to HLA-B* 27 alleles, 12 loci have previously been identified …

Osteoarthritis (OA) is characterised by an irreversible degeneration of articular cartilage.
Here we show that the BMP-antagonist Gremlin 1 (Grem1) marks a bipotent chondrogenic …

The human microbiome consists of all microorganisms occupying the skin, mucous
membranes and intestinal tract of the human body. The contact of the mucosal immune …

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that affects the spine and
sacroiliac joints. It causes significant disability and is associated with a number of other …

Spondyloarthritis is the second most common form of chronic inflammatory arthritis and a
unique hallmark of the disease is pathologic new bone formation. Several cytokine …

Del-1 is an endothelial cell-secreted anti-inflammatory protein. In humans and mice, Del-1
expression is inversely related to that of IL-17, which inhibits Del-1 through hitherto …

The inflammatory diseases that are most strongly associated with major histocompatibility
Complex class I (MHC-I) alleles are also influenced by endoplasmic reticulum …

HAPLN1 maintains aggregation and the binding activity of extracellular matrix (ECM)
molecules (such as hyaluronic acid and proteoglycan) to stabilize the macromolecular …